Adaptive Time-Resolved Mass Spectrometry With Nanomechanical Resonant Sensors

Nanomechanical resonant sensors that are based on detecting and tracking the resonance frequency deviations due to events of interest being advocated for a variety applications. All sensor schemes currently in use subject basic trade-off between accuracy speed, while there is great improving both order enable unprecedented widespread Based thorough understanding characteristics current architectures, we propose adaptive flexible schemes. Unlike recently proposed time-resolved mechanical detection methods, do not require ensemble averaging resonator response many independent identical stimuli. Distinct one-time can be detected real-time with high time resolution an then improves considerably elapsed time. While also need abide by fundamental speed versus trade-off, show still "some room at bottom" improvement architecture innovations. Pareto optimal performance reaches bound imposed thermomechanical noise achieved.